The top industries in Minnesota by overall economic output are professional and business services, finance, insurance, and real estate, and manufacturing, while the state maintains deep national leadership in healthcare, medical technology, clean energy, and corporate management. Minnesota is home to 18 of the Fortune 500 companies, alongside the nation's largest privately held corporation, Cargill, and the globally renowned Mayo Clinic. Its powerhouse corporate ecosystem includes 3M, Best Buy, Ecolab, General Mills, Hormel, Target, U.S. Bank, UnitedHealth Group, and Xcel Energy, while Medtronic continues to base its primary operational headquarters in the state.